Best Vacation Homes in Santee
5 Guests
3 Bedrooms
2 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $163/Night
For 7 Nights US $1,141
3401.4 ft²
9 Guests
1 Bedroom
3 Bathrooms
Free Cancellation
House
- Fireplace/Heating
- Pet Friendly
- Parking
US $363/Night
For 7 Nights US $2,539
1 Bathroom
Family Friendly
Hotel
- Pool
- Balcony/Terrace
- Breakfast
US $149/Night
For 7 Nights US $1,041
6 Guests
2 Bedrooms
2 Bathrooms
Family Friendly
Condo
- Hot Tub
- Fireplace/Heating
- Pool
US $252/Night
For 7 Nights US $1,765
904.17 ft²
4 Guests
1 Bedroom
2 Bathrooms
Free Cancellation
House
- Fireplace/Heating
- Pet Friendly
- Parking
US $323/Night
For 7 Nights US $2,259
1227 ft²
6 Guests
2 Bedrooms
2 Bathrooms
Ocean View
Condo
- Hot Tub
- Fireplace/Heating
- Pool
US $243/Night
For 7 Nights US $1,701
5 Guests
2 Bedrooms
2 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Balcony/Terrace
- Kitchen
US $223/Night
For 7 Nights US $1,560
6 Guests
2 Bedrooms
2 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $263/Night
For 7 Nights US $1,841
Santee Luxury Rentals
30 Guests
10 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $1,422/Night
For 7 Nights US $9,954
30 Guests
10 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $1,422/Night
For 7 Nights US $9,954
30 Guests
10 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $1,422/Night
For 7 Nights US $9,954
30 Guests
10 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $1,422/Night
For 7 Nights US $9,954
30 Guests
10 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $1,422/Night
For 7 Nights US $9,954
24 Guests
8 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $1,138/Night
For 7 Nights US $7,966
24 Guests
8 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $1,138/Night
For 7 Nights US $7,966
24 Guests
8 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $1,138/Night
For 7 Nights US $7,966
Santee Pet Friendly Vacation Rentals
1300 ft²
5 Guests
1 Bedroom
2 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Balcony/Terrace
- Pet Friendly
US $270/Night
For 7 Nights US $1,893
US $156/Night
For 7 Nights US $1,089
US $72/Night
For 7 Nights US $503
6 Guests
2 Bedrooms
2 Bathrooms
Family Friendly
House
- Fireplace/Heating
- Balcony/Terrace
- Pet Friendly
US $196/Night
For 7 Nights US $1,369
US $133/Night
For 7 Nights US $933
8 Guests
2 Bedrooms
1 Bathroom
Pet Friendly
Cottage
- Pet Friendly
- Air Conditioner
- Internet
US $216/Night
For 7 Nights US $1,513
8 Guests
2 Bedrooms
2 Bathrooms
Family Friendly
House
- Fireplace/Heating
- Pet Friendly
- Air Conditioner
US $264/Night
For 7 Nights US $1,845
8 Guests
2 Bedrooms
2 Bathrooms
Family Friendly
Condo
- Hot Tub
- Fireplace/Heating
- Pool
US $366/Night
For 7 Nights US $2,564
Santee Large Vacation Homes
10 Guests
2 Bedrooms
2 Bathrooms
Ocean View
Condo
- Fireplace/Heating
- Pool
- Ocean View
US $204/Night
For 7 Nights US $1,430
1388.55 ft²
24 Guests
5 Bedrooms
2 Bathrooms
Apartment
- Pool
- Parking
- Air Conditioner
US $139/Night
For 7 Nights US $973
1730 ft²
10 Guests
3 Bedrooms
2 Bathrooms
Family Friendly
House
- Fireplace/Heating
- Balcony/Terrace
- Pet Friendly
US $339/Night
For 7 Nights US $2,373
274.48 ft²
12 Guests
4 Bedrooms
1 Bathroom
Family Friendly
Cabin
- Hot Tub
- Fireplace/Heating
- View
US $73/Night
For 7 Nights US $508
10 Guests
3 Bedrooms
3 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $374/Night
For 7 Nights US $2,618
10 Guests
3 Bedrooms
3 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $364/Night
For 7 Nights US $2,548
20 Guests
6 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $718/Night
For 7 Nights US $5,026
20 Guests
6 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $715/Night
For 7 Nights US $5,005
Why Choose Rent By Owner for your Santee Vacation Rental Homes?
What makes our Vacation Rentals special?
Verified Listings
Book with confidence knowing every property meets our quality and safety standards.
Unbeatable Value
Enjoy competitive pricing with no hidden fees, providing exceptional value for every stay.
Diverse Options
From cozy cabins to luxurious villas, find a rental that suits your style and needs.
Best Times to Visit Santee
When should you plan your Vacation Rentals stay?
Choosing the ideal time to visit this destination ensures you can fully enjoy the region’s seasonal charm and outdoor activities, making your vacation rental experience memorable and stress-free.
Peak Season Highlights
Summer (June to August)
During the summer months, this area experiences warm weather that is ideal for outdoor activities and water-based adventures.
Average Temperature Daytime: 85°F to 90°F - Nighttime: 65°F to 70°F
Spring (March to May)
Springtime here brings pleasant temperatures and blooming landscapes, perfect for exploring and enjoying outdoor pursuits.
Average Temperature Daytime: 75°F to 80°F - Nighttime: 55°F to 60°F
Off-Season Highlights
Fall (September to November)
As the weather cools, fewer visitors arrive, offering a more peaceful experience in the region's natural setting.
Average Temperature Daytime: 70°F to 75°F - Nighttime: 50°F to 55°F
Winter (December to February)
Winter months bring cooler temperatures and lower occupancy, making it an ideal time for those seeking tranquility and lower rates.
Average Temperature Daytime: 55°F to 60°F - Nighttime: 40°F to 45°F
Weekly Weather Forecast for Santee
How to Book Your Santee Vacation Rental Home
What's our booking process?
Our platform allows you to browse a curated selection of vacation rentals. Once you find the ideal property, you’ll be redirected to a trusted booking partner to complete your reservation securely.
Booking Steps
01
Search Properties
Use our filters to find the right property that fits your needs.
02
Select a Rental
Click on your preferred listing to view details, amenities, and pricing.
03
Book Online
Follow the link to finalize your reservation directly on the partner’s website.
Explore and book the perfect rental in Santee
Common Vacation Rentals Amenities
What amenities can you expect?
Our Vacation Rentals are designed to offer all the comforts of home, often with added perks to make your stay unforgettable. Here’s some common amenities to look forward to:
Indoor Features
- Fully-equipped kitchens with modern appliances
- Comfortable living areas with flat-screen TVs
- Free Wi-Fi for staying connected
- Air conditioning and heating for year-round comfort
- In-unit washers and dryers for convenience
- Luxurious bedrooms with premium bedding
- Spa-like bathrooms with soaking tubs or walk-in showers
Outdoor Amenities
- Enjoy outdoor grilling with access to a barbecue pit or grill area
- Relax by a private or shared swimming pool, perfect for warm days
- Take advantage of spacious patios or decks for outdoor dining and gatherings
- Experience scenic views from outdoor seating areas or verandas
- Make use of well-maintained lawns and gardens for leisurely strolls or outdoor activities
- Access to boat docks or fishing piers if you’re interested in water-based recreation
- Utilize outdoor recreational facilities such as volleyball courts or playgrounds
Top Attractions Around Santee
What attractions are nearby?
In this charming destination, you can enjoy a variety of outdoor activities such as fishing, boating, and exploring scenic parks that showcase the natural beauty of the region.
Family Activities
- Santee National Wildlife Refuge: Explore this expansive refuge to enjoy birdwatching, nature trails, and family-friendly educational programs amidst the area's natural beauty.
- Santee Cooper Country Park: Spend quality time outdoors at this scenic park offering picnic areas, playgrounds, and boat rentals for a fun day by the water.
- Lake Marion Water Activities: Engage in boating, fishing, or paddleboarding on Lake Marion, a highlight of the region that guarantees memorable outdoor adventures for your family.
- Santee Regional Library: Visit for storytimes, kid-friendly activities, and a cozy space to relax with books after exploring the area’s outdoor attractions.
Adult Activities
- Santee State Park: Explore this scenic park offering opportunities for hiking, birdwatching, and enjoying the natural beauty of the region's lakes and forests.
- Lake Marion: Spend your day engaging in fishing, boating, or simply relaxing along the shores of this large, accessible lake in the area.
- Santee Cooper Country: Discover local golf courses, nature trails, and outdoor activities that showcase the region's outdoor appeal for active adults.
- Local Dining Experiences: Indulge in the area's renowned Southern cuisine at various restaurants, perfect for savoring local flavors after a day of adventure.
Other Places to Stay in Santee, SC
Santee Cooper Country Club
Santee Outlets
Santee National Golf Club
Santee State Park
Santee Travel Tips
How Can You Make the Most of Your Stay?
- Plan Ahead for Local Activities: Research popular outdoor activities and attractions available in this region to maximize your leisure time during your stay.
- Select a Well-Situated Vacation Rental: Choose a property that offers convenient access to the area's main sites and natural settings, enhancing your overall experience.
- Explore Off-the-Beaten-Path Spots: Take time to discover lesser-known areas nearby to enjoy a more authentic and tranquil side of this destination.
- Respect Local Environment and Community: Practice eco-friendly habits and support local businesses to contribute positively to the region’s sustainability and charm.
Transportation Options
- South Carolina Highway 6 Bus Service: This regional bus service offers convenient transportation for exploring the surrounding area and reaching nearby towns from your vacation rental.
- Santee Cooper Transit: A reliable local transit option providing routes that connect you to key spots around here, making it easier to navigate without a car.
- Rental Car Services: Numerous rental agencies operate nearby, giving you the flexibility and comfort to explore this destination at your own pace.
- Taxis and Rideshare Options: On-demand services like taxis and rideshares are readily available, helping you get around comfortably during your stay here.
Local Customs Options
- Southern Hospitality: Welcoming visitors with warmth and friendliness is a cherished tradition that you'll notice in the local community.
- Fishing Etiquette: Respect for fishing customs, especially around the area's lakes and rivers, is highly valued among residents and visitors alike.
- Local Cuisine:** Enjoying regional dishes like shrimp and grits or barbecue reflects the area's rich culinary heritage, often shared during communal gatherings.
- Historical Preservation: Honoring the area's history through preservation efforts and respectful tours offers insight into this destination's unique past.
Frequently Asked Questions About Santee?
1. What are the top vacation rentals in Santee?
There are a lot of options in Santee. If you plan on staying in the Santee area, consider making a reservation for a few nights at one of these properties as these have been rated the Top Vacation Rentals in Santee:
- Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
- Lovely Condo w/pool, balcony, and lakeside view!
- Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
- Lake Marion - Majestic Big Water View!
- Waterfront Condo on Lake Marion
- Fully renovated 1959 lake front cottage. In-ground swimming pool and spa.
- Lakeside Bliss: 3BR Suite at Wyndham Lake Marion
- Lakeside Bliss: 3BR Suite at Wyndham Lake Marion
- 2br Deluxe Unit Tranquil Shores of Lake Marion
- Lakefront Retreat on Lake Marion – Perfect for Fishing & Relaxation
2. How many vacation rentals have private pools in Santee?
There are 4 vacation rentals with private pools near Santee. Top-rated RBO homes that have access to a swimming pool include:
3. Which vacation homes in Santee are best for families?
If you are looking for a family-friendly vacation home in Santee, check out one of the following properties as all are highly-rated places to stay with excellent review for families or groups staying in Santee:
4. How many Rentbyowner vacation rentals are available in Santee?
Currently, the total number of properties listed by Rent By Owner in 2026 is over 171 in the Santee area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in Santee.
5. What is the cancellation policy for vacation rentals in Santee, South Carolina?
Cancellation policies can vary depending on the specific property you choose. It is recommended to review the listing details or contact the property owner directly to understand the applicable cancellation terms before booking.
6. How do I find available dates and secure my stay at a vacation rental here?
You can check the availability calendar on the listing page and proceed with the booking process online. For any questions about availability or reservations, reaching out to the property owner is advised to ensure your preferred dates are secured.
7. Are there any specific house rules or requirements I should be aware of during my stay?
Each property in the area may have its own set of house rules and guest requirements. These are typically detailed in the listing description, but contacting the owner directly can provide additional clarification to ensure a smooth stay.
8. What amenities are commonly included in vacation rentals around this destination?
Most properties offer essential amenities such as Wi-Fi, kitchen facilities, and laundry options. For specific features like pools or pet accommodations, it’s best to review the individual listing details or ask the owner directly.
9. Is there a minimum stay requirement for booking a vacation rental in this region?
Minimum stay policies can differ from one property to another. To confirm the length of stay required and avoid any surprises, make sure to review the booking terms listed for each property or contact the owner directly.
Santee Top Rated Vacation Rentals
1700 ft²
6 Guests
3 Bathrooms
Family Friendly
Resort
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $413/Night
For 7 Nights US $2,890
8 Guests
4 Bedrooms
2 Bathrooms
Ocean View
House
- Private Pool
- Hot Tub
- Fireplace/Heating
US $597/Night
For 7 Nights US $4,176
12 Guests
4 Bedrooms
1 Bathroom
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $569/Night
For 7 Nights US $3,983
10 Guests
3 Bedrooms
3 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $363/Night
For 7 Nights US $2,541
10 Guests
3 Bedrooms
3 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $363/Night
For 7 Nights US $2,541
1227 ft²
6 Guests
2 Bedrooms
2 Bathrooms
Ocean View
Condo
- Hot Tub
- Fireplace/Heating
- Pool
US $243/Night
For 7 Nights US $1,701
1210 ft²
6 Guests
2 Bedrooms
2 Bathrooms
Family Friendly
Condo
- Fireplace/Heating
- Pool
- Balcony/Terrace
US $251/Night
For 7 Nights US $1,760
US $150/Night
For 7 Nights US $1,050
