Discover Your Perfect Mayo Clinic Vacation Homes

Best Vacation Homes in Mayo Clinic

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10.0 (5 Reviews)
Apartment
District Attorney's Office
  • Air Conditioner
  • Parking
  • Pet Friendly
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10.0 (5 Reviews)
Apartment
City Hall Clerk's Office
  • Air Conditioner
  • Pet Friendly
  • Accessibility
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Why Choose Rent By Owner for your Mayo Clinic Vacation Rental Homes?

What makes our Vacation Rentals special?

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Verified Listings
Book with confidence knowing every property meets our quality and safety standards.
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Unbeatable Value
Enjoy competitive pricing with no hidden fees, providing exceptional value for every stay.
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Diverse Options
From cozy cabins to luxurious villas, find a rental that suits your style and needs.

Popular Areas for Mayo Clinic Vacation Rentals

Where are the best neighborhoods to stay in Mayo Clinic?

When choosing a neighborhood to stay in near the Mayo Clinic in Rochester, Minnesota, you’ll find a variety of options that cater to different preferences and needs. The area surrounding this renowned medical center offers peaceful residential communities, vibrant downtown districts, and convenient neighborhoods with easy access to major highways and local amenities. Whether you're seeking a quiet retreat or a lively atmosphere, selecting the right neighborhood will enhance your visit and provide a comfortable home base during your time in Rochester. Explore our selection of vacation rentals in the vicinity to enjoy a seamless and trustworthy booking experience tailored to your travel plans.

Downtown

Staying downtown offers easy access to the heart of the city, making it convenient for medical visits and exploring local amenities in this vibrant area of Rochester. It's an ideal choice if you want to be close to urban attractions while enjoying comfortable vacation rentals.

View 344+ Rentals in Downtown

Glendale

Located in a peaceful part of the region, Glendale provides a quiet retreat with scenic views, perfect for relaxing after busy days at the Mayo Clinic. Here, you can find cozy vacation rentals situated amidst natural beauty.

View 377+ Rentals in Glendale

Historic Southwest

Known for its charming architecture and historic ambiance, Historic Southwest offers a unique stay experience with convenient access to the area's cultural landmarks and medical facilities. It’s an excellent neighborhood for those seeking a blend of history and comfort.

View 307+ Rentals in Historic Southwest

Northrup

This neighborhood provides a welcoming environment with close proximity to key healthcare centers and local amenities, making it a practical choice for visitors to the region. Vacation rentals here offer both convenience and comfort.

View 511+ Rentals in Northrup

Kutzky Park

Nestled near green spaces, Kutzky Park is perfect for outdoor enthusiasts who prefer staying in a friendly, community-focused area with easy access to medical facilities. The neighborhood offers a range of comfortable vacation rentals.

View 108+ Rentals in Kutzky Park

East Side Pioneers

This historic neighborhood showcases the pioneering spirit of Rochester and provides a more authentic experience for visitors seeking a neighborhood with character and convenient access to the region's healthcare institutions.

View 481+ Rentals in East Side Pioneers

Slatterly Park

With its picturesque parks and family-friendly environment, Slatterly Park is an appealing choice for relaxation while being close to medical centers and amenities in the area. Vacation rentals here combine comfort and accessibility.

View 490+ Rentals in Slatterly Park

John Adams

Offering a mix of residential charm and practicality, John Adams is well-suited for visitors looking for a quiet neighborhood near the city's essential services. This area features a variety of pleasant vacation rental options.

View 419+ Rentals in John Adams

Best Times to Visit Mayo Clinic

When should you plan your Vacation Rentals stay?

Choosing the right time to visit here can greatly enhance your experience, whether you're seeking the vibrant seasons or quieter periods in this region known for its welcoming community and serene environment.

Peak Season Highlights

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Summer (June to August)

During summer, the region experiences warm temperatures and longer daylight hours, making it an ideal time for visitors seeking comfortable weather conditions in this destination.

Average Temperature Daytime: 75°F to 85°F - Nighttime: 55°F to 65°F
autumn
Fall (September to November)

Autumn brings mild temperatures and vibrant foliage, providing a picturesque setting that attracts travelers looking to enjoy the scenic beauty of this area.

Average Temperature Daytime: 60°F to 70°F - Nighttime: 40°F to 50°F

Off-Season Highlights

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Winter (December to February)

In winter, colder weather prevails, often with snow covering the landscape. This is suitable for visitors who appreciate a quieter visit during the colder months.

Average Temperature Daytime: 20°F to 30°F - Nighttime: 5°F to 15°F
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Early Spring (March to May)

As the region transitions into spring, temperatures are still relatively cool, offering a peaceful atmosphere for those seeking fewer crowds and lower rates.

Average Temperature Daytime: 40°F to 55°F - Nighttime: 25°F to 35°F

Weekly Weather Forecast for Mayo Clinic

How to Book Your Mayo Clinic Vacation Rental Home

What's our booking process?

Our platform allows you to browse a curated selection of vacation rentals. Once you find the ideal property, you’ll be redirected to a trusted booking partner to complete your reservation securely.

Booking Steps

01

Search Properties

Use our filters to find the right property that fits your needs.
02

Select a Rental

Click on your preferred listing to view details, amenities, and pricing.
03

Book Online

Follow the link to finalize your reservation directly on the partner’s website.

Explore and book the perfect rental in Mayo Clinic

More Top-Rated Vacation Rentals in Mayo Clinic Area

Common Vacation Rentals Amenities

What amenities can you expect?

Our Vacation Rentals are designed to offer all the comforts of home, often with added perks to make your stay unforgettable. Here’s some common amenities to look forward to:

Indoor Features

  • Fully-equipped kitchens with modern appliances
  • Comfortable living areas with flat-screen TVs
  • Free Wi-Fi for staying connected
  • Air conditioning and heating for year-round comfort
  • In-unit washers and dryers for convenience
  • Luxurious bedrooms with premium bedding
  • Spa-like bathrooms with soaking tubs or walk-in showers

Outdoor Amenities

  • Enjoy a private outdoor patio or deck to relax and unwind after exploring the area.
  • Take advantage of spacious yards, perfect for outdoor activities or family gatherings.
  • Make use of outdoor grilling facilities to host enjoyable barbecues in the fresh air.
  • Relax by the outdoor fire pit during cool evenings under the stars.
  • Stroll through beautifully landscaped gardens surrounding your rental property.
  • Access to nearby parks or outdoor recreation areas for walking, biking, or picnicking.
  • If available, dip into an outdoor pool to cool off and enjoy the sunny weather here.

Top Attractions Around Mayo Clinic

What attractions are nearby?

Enjoy a variety of outdoor activities, cultural experiences, and local attractions just moments from your vacation rentals in the Rochester area, making it easy to explore everything this destination has to offer during your stay.

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Family Activities

  • Rochester Civic Theater: Enjoy live performances and family-friendly shows at this historic venue in the heart of the city, offering cultural entertainment for all ages.
  • Mayo Civic Center: Participate in engaging community events and exhibitions held within the region, providing fun and educational experiences for families visiting here.
  • Oxbow Park and Zoo: Explore this local zoo that features native Minnesota animals and offers interactive exhibits perfect for a day of family discovery and wildlife appreciation.
  • Silver Lake Park: Relax and play at this scenic park offering walking trails, playgrounds, and picturesque views, making it an ideal spot for outdoor family activities near your vacation rental.
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Adult Activities

  • Explore the Mayo Civic Center: Attend engaging concerts, conferences, or cultural events that showcase the region’s vibrant community spirit.
  • Visit Quarry Hill Nature Center: Immerse yourself in the natural beauty of this destination by enjoying scenic walking trails and wildlife exhibits.
  • Discover the Shops at University Square: Experience shopping at boutique stores and dine at local eateries to unwind after your day of exploration.
  • Enjoy a round of golf at Rochester Golf & Country Club: Tee off amidst picturesque fairways designed for both beginners and seasoned players, offering relaxation in the area's lush surroundings.

Mayo Clinic Travel Tips

How Can You Make the Most of Your Stay?

  • Plan Your Transportation: Arrange reliable transportation options in advance to easily navigate the area and maximize your time around Mayo Clinic, Rochester.
  • Choose a Strategic Location: Select vacation rentals close to the main medical facilities to reduce commute times and enhance your overall experience during your stay.
  • Explore Local Amenities: Take advantage of nearby dining, shopping, and wellness amenities to make your visit comfortable and convenient.
  • Prepare for Your Visit: Pack essentials tailored to your healthcare schedule and consider booking accommodations with flexible check-in options to adapt to your appointment times.

Transportation Options

  • Rochester Transit Service (RTS): This local bus system offers convenient transit options to navigate around the area and access key destinations near your vacation rental.
  • Rochester International Airport: Serving as the primary gateway, this airport provides domestic flights that make traveling to and from here straightforward and efficient.
  • Taxi Services and Rideshares: Reliable taxi companies and rideshare options like Uber and Lyft are readily available for flexible transportation during your stay.
  • Car Rentals: Multiple car rental agencies operate at the airport and in the city, giving you the freedom to explore the region at your own pace.

Local Customs Options

  • Hospitality and Politeness: You will notice that courteous interactions and respectful behavior are deeply rooted in the local customs, reflecting the area's welcoming spirit.
  • Greetings and Handshakes: A firm handshake is a common way to greet others here, emphasizing professionalism and friendliness in both social and medical environments.
  • Respect for Privacy: Personal space and privacy are highly valued, especially within healthcare settings, making it important to be considerate of others' boundaries during your stay.
  • Observance of Quiet Hours: Maintaining a quiet environment is appreciated in this destination, ensuring a peaceful atmosphere that aligns with the region’s calm and considerate community ethos.

Frequently Asked Questions About Mayo Clinic?

1. What are the top vacation rentals in Mayo Clinic?

There are a lot of options in Mayo Clinic. If you plan on staying in the Mayo Clinic area, consider making a reservation for a few nights at one of these properties as these have been rated the Top Vacation Rentals in Mayo Clinic:

2. How many Rentbyowner vacation rentals are available in Mayo Clinic?

Currently, the total number of properties listed by Rent By Owner in 2025 is over 505 in the Mayo Clinic area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in Mayo Clinic. 

3. What is the cancellation policy for vacation rentals near Mayo Clinic in Rochester?

Cancellation policies vary depending on the host and specific listing. You should review the individual rental's cancellation terms on the property page or contact the owner directly to understand the applicable rules and potential fees.

4. Are there any specific check-in and check-out times for vacation rentals close to Mayo Clinic?

Check-in and check-out times are set by each host. Details are typically provided on the listing page, so be sure to verify these times before booking or contact the property owner for clarification.

5. How do I find pet-friendly vacation rentals in the Rochester area?

Pet-friendly options are available but vary by listing. Use the search filters on the booking site to specify your needs, and review the property description to confirm whether pets are accepted.

6. What amenities can I expect from vacation rentals near Mayo Clinic during my stay?

Amenities differ among properties, but common offerings include Wi-Fi, kitchen facilities, and parking. Always check the property details or contact the owner for a complete list of available amenities.

7. How do I ensure the safety and cleanliness of vacation rentals in this region?

Host standards and cleaning protocols are outlined in each listing. For additional assurance, read guest reviews and reach out to the owner with any specific safety concerns or questions about sanitation procedures.

Best Vacation Homes in Mayo Clinic