Discover Your Perfect Mission Bay Vacation Homes

Best Vacation Homes in Mission Bay

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Mission Bay Luxury Rentals

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Mission Bay Pet Friendly Vacation Rentals

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Mission Bay Large Vacation Homes

9.4 (75 Reviews)
Bed & Breakfast
Chateau Tivoli Bed and Breakfast
  • Security/Safety
  • Sports/Activities
  • Fireplace/Heating
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Why Choose Rent By Owner for your Mission Bay Vacation Rental Homes?

What makes our Vacation Rentals special?

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Verified Listings
Book with confidence knowing every property meets our quality and safety standards.
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Unbeatable Value
Enjoy competitive pricing with no hidden fees, providing exceptional value for every stay.
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Diverse Options
From cozy cabins to luxurious villas, find a rental that suits your style and needs.

Popular Areas for Mission Bay Vacation Rentals

Where are the best neighborhoods to stay in Mission Bay?

When choosing a neighborhood to stay in San Francisco, California, exploring the vibrant Mission Bay offers a unique blend of modern convenience and scenic views. Located near the heart of the city, this area provides easy access to many popular attractions while maintaining a peaceful atmosphere ideal for relaxation. Whether you're seeking a lively environment or a quiet retreat, Mission Bay's diverse neighborhoods cater to different preferences, making it an excellent choice for your next getaway. Booking your vacation rental here ensures you experience comfort and convenience in one of San Francisco's most desirable locations.

Downtown San Francisco

Staying near the heart of the city puts you within easy reach of vibrant businesses and cultural attractions, making this a dynamic choice for your visit.

View 354+ Rentals in Downtown San Francisco

South of Market

This lively neighborhood offers modern amenities and proximity to the region’s innovation hubs, ideal for those seeking a contemporary urban experience.

View 90+ Rentals in South of Market

South Beach

Known for its scenic waterfront views and trendy atmosphere, here you can enjoy both relaxation and entertainment just minutes from your destination.

View 503+ Rentals in South Beach

Potrero Hill

Offering stunning vistas and a quieter atmosphere, this neighborhood is perfect for guests who want a peaceful retreat while still being close to the bustling city center.

View 2574+ Rentals in Potrero Hill

China Basin

Situated near major sports and tech venues, this area caters to travelers looking for an energetic environment with convenient access to local attractions.

View 504+ Rentals in China Basin

Dogpatch

This historic district blends industrial charm with modern developments, providing an authentic San Francisco experience combined with easy access to the waterfront.

View 2552+ Rentals in Dogpatch

Central Waterfront

Enjoy the scenic views and tranquil atmosphere along the bay here, making it an excellent base for exploring the region’s natural beauty and landmarks.

View 2499+ Rentals in Central Waterfront

Best Times to Visit Mission Bay

When should you plan your Vacation Rentals stay?

Choosing the optimal time to visit this destination can enhance your experience, as the area's mild climate and seasonal events make certain periods ideal for booking your vacation rentals here in Mission Bay, San Francisco.

Peak Season Highlights

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Summer (June to August)

During the summer months, you can enjoy warm weather and longer daylight hours when visiting the area. This is the busiest time for the region, so booking your vacation rentals early is highly recommended.

Average Temperature Daytime: 70-75°F - Nighttime: 55-60°F
autumn
Fall (September to November)

Early fall brings mild temperatures and fewer crowds, making it an ideal time to explore this destination while still experiencing the lively ambiance of the region’s peak season.

Average Temperature Daytime: 65-70°F - Nighttime: 50-55°F

Off-Season Highlights

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Winter (December to February)

With cooler temperatures and less tourist activity, winter offers a quieter experience while still allowing you to enjoy the area's scenic views and indoor attractions.

Average Temperature Daytime: 55-60°F - Nighttime: 45-50°F
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Spring (March to May)

As the season transitions, you'll find fewer visitors and comfortable weather, perfect for exploring the region at a relaxed pace without the summer crowds.

Average Temperature Daytime: 60-65°F - Nighttime: 50-55°F

Weekly Weather Forecast for Mission Bay

How to Book Your Mission Bay Vacation Rental Home

What's our booking process?

Our platform allows you to browse a curated selection of vacation rentals. Once you find the ideal property, you’ll be redirected to a trusted booking partner to complete your reservation securely.

Booking Steps

01

Search Properties

Use our filters to find the right property that fits your needs.
02

Select a Rental

Click on your preferred listing to view details, amenities, and pricing.
03

Book Online

Follow the link to finalize your reservation directly on the partner’s website.

Explore and book the perfect rental in Mission Bay

More Top-Rated Vacation Rentals in Mission Bay Area

Common Vacation Rentals Amenities

What amenities can you expect?

Our Vacation Rentals are designed to offer all the comforts of home, often with added perks to make your stay unforgettable. Here’s some common amenities to look forward to:

Indoor Features

  • Fully-equipped kitchens with modern appliances
  • Comfortable living areas with flat-screen TVs
  • Free Wi-Fi for staying connected
  • Air conditioning and heating for year-round comfort
  • In-unit washers and dryers for convenience
  • Luxurious bedrooms with premium bedding
  • Spa-like bathrooms with soaking tubs or walk-in showers

Outdoor Amenities

  • Enjoy outdoor seating areas to relax and take in the scenic views surrounding the area.
  • Benefit from private or communal patios, perfect for dining or unwinding after a day exploring.
  • Take advantage of outdoor grills provided for convenient barbecues with friends or family.
  • Relax in lush landscaped gardens that provide a peaceful setting within the property grounds.
  • Utilize dedicated bike storage or racks to explore the region via cycling paths nearby.
  • Access waterfront views and walking paths along the bay for outdoor recreation and leisurely strolls.
  • Make use of swimming pools or hot tubs available on-site to enjoy the pleasant regional climate.

Top Attractions Around Mission Bay

What attractions are nearby?

In this vibrant area, you can enjoy a variety of outdoor activities such as kayaking, paddleboarding, and walking along scenic waterfront trails, all just moments from your vacation rental in Mission Bay, San Francisco.

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Family Activities

  • Mission Bay Park: Take your family for a relaxing day at this expansive urban park, perfect for picnics, playground visits, and enjoying scenic waterfront views.
  • Aquatic Park: Explore the calm waters and sandy shores ideal for children to play and families to indulge in kayaking or paddleboarding here in the region.
  • Children’s Creativity Museum: Engage your kids with interactive art and technology exhibits that foster creativity in an inspiring setting close to Mission Bay.
  • Ghirardelli Square: Satisfy sweet cravings and explore boutique shops at this iconic destination nearby, making it a delightful outing for the whole family.
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Adult Activities

  • Kayaking and Paddleboarding: Explore the calm waters of the area on a kayak or paddleboard, enjoying scenic views and a relaxing way to connect with nature.
  • Walking and Biking Trails: Discover local trails along the waterfront that are perfect for a leisurely stroll or an invigorating bike ride through the region.
  • Harbor Cruises: Experience the region from a different perspective by taking a harbor cruise that offers stunning views of the city skyline and surrounding bay area.
  • Dining at Waterfront Restaurants: Savor fresh, locally sourced cuisine at waterfront eateries that provide a perfect setting for a leisurely adult dining experience in this destination.

Other Places to Stay in Mission Bay, CA

Mission Creek Park
Mission Creek Park Vacation Rentals
UCSF Mission Bay
UCSF Mission Bay Vacation Rentals
Lefty O'Doul Bridge
Lefty O'Doul Bridge Vacation Rentals
Chase Center
Chase Center Vacation Rentals
UCSF Benioff Children's Hospital
UCSF Benioff Children's Hospital Vacation Rentals
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Mission Bay Travel Tips

How Can You Make the Most of Your Stay?

  • Plan Your Transportation: Take advantage of the area’s biking and public transit options to explore Mission Bay and its surroundings effortlessly.
  • Discover Local Dining: Sample the region’s diverse cuisine at nearby restaurants, giving you a taste of the local culinary scene right outside your vacation rental.
  • Explore Waterfront Activities: Make the most of the scenic views by engaging in water-based activities or relaxing by the bay’s cheerful waterfront areas.
  • Visit Nearby Attractions: Use your convenient location to visit popular attractions around the city, ensuring you experience the best of what this destination offers.

Transportation Options

  • Bay Area Rapid Transit (BART): You can easily access the regional transit system from here to explore San Francisco and surrounding areas efficiently.
  • San Francisco Municipal Transportation Agency (Muni): The local bus and streetcar services provide convenient transportation within this vibrant part of the city.
  • Bike Sharing Programs: Renting a bike offers a flexible way to navigate the scenic surroundings and enjoy outdoor activities nearby.
  • Ride-Sharing Services: Apps like Uber and Lyft are readily available for quick, reliable trips throughout the region.

Local Customs Options

  • Local Seafood Cuisine: Savor the fresh seafood dishes that are a staple in the area, reflecting its vibrant maritime culture.
  • Respect for Waterfront Recreation: When visiting parks and water activities, it’s customary to follow local guidelines to preserve the natural beauty of this bay-front destination.
  • Participation in Community Events: Engaging in neighborhood festivals and outdoor gatherings is a common way for visitors to embrace the area's lively social scene.
  • Environmental Conservation Practices: Supporting local initiatives such as recycling and eco-friendly practices helps maintain the region's pristine environment for everyone to enjoy.

Frequently Asked Questions About Mission Bay?

1. What are the top vacation rentals in Mission Bay?

There are a lot of options in Mission Bay. If you plan on staying in the Mission Bay area, consider making a reservation for a few nights at one of these properties as these have been rated the Top Vacation Rentals in Mission Bay:

2. How many vacation rentals have private pools in Mission Bay?

There are 41 vacation rentals with private pools near Mission Bay. Top-rated RBO homes that have access to a swimming pool include:

3. Which vacation homes in Mission Bay are best for families?

If you are looking for a family-friendly vacation home in Mission Bay, check out one of the following properties as all are highly-rated places to stay with excellent review for families or groups staying in Mission Bay:

4. How many Rentbyowner vacation rentals are available in Mission Bay?

Currently, the total number of properties listed by Rent By Owner in 2025 is over 3096 in the Mission Bay area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in Mission Bay. 

5. What is the cancellation policy for vacation rentals in this area?

Cancellation policies vary depending on the individual property listing. It is recommended that you review the specific cancellation terms outlined in the rental details or contact the owner directly to understand your options and any applicable fees.

6. How do I check the availability of a vacation rental in the region?

Availability can be confirmed by entering your desired dates on the listing page. If options are limited or unclear, reaching out to the property owner can provide additional insight and assistance.

7. Are there any house rules or restrictions I should be aware of before booking?

Yes, each property has its own set of house rules, which are detailed in the listing description. To ensure a smooth stay, review these rules carefully and contact the owner if you have any questions.

8. What amenities are typically included in vacation rentals in this destination?

Most properties offer amenities such as Wi-Fi, kitchen facilities, and parking. For specifics, always refer to the property listing or ask the owner directly to confirm available features.

9. How do I inquire about special requests or additional services for my stay?

You can contact the property owner through the messaging platform provided on the listing page. They can assist with special requests or provide information on available add-on services to enhance your visit here.

Mission Bay Top Rated Vacation Rentals

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