Sleeps24*Louisville*6000SF*Views*YardOasis*HotTub*Dome*Firepit*Pet*Lux Amenities | House in Jeffersonville

~ Deaconess Guesthouse — Historic Elegance on the Ohio River, Minutes from Louisville & Jeffersonville ~
★ Where History Meets Modern Luxury:
Step into timeless sophistication at Deaconess Guesthouse, a masterfully reimagined 1800s landmark that once served as Jeffersonville’s first public hospital. Painstakingly restored by Charming Vacation Homes, this distinguished estate blends rich history with refined, boutique-style living. Overlooking the serene Ohio River and just minutes from downtown Louisville, the Bourbon Trail, and Jeffersonville’s lively riverfront district, it offers an experience that is both captivating and unforgettable.
★ Designed for Connection & Celebration:
With 8 beautifully appointed bedrooms and 6 spa-inspired bathrooms across four private suites, the estate accommodates up to 24 guests in absolute comfort. Perfect for family reunions, executive retreats, weddings, and milestone celebrations, the home’s thoughtful layout provides an ideal balance of gathering spaces and peaceful privacy. Every corner—from the grand living areas to the artfully curated décor—has been designed to inspire conversation, laughter, and lasting memories.
★ Signature Amenities & Exclusive Touches:
1. Private Hot Tub & Fire Pit – Relax under the stars in your own riverfront sanctuary
2. Wraparound Porches & Scenic Balconies – Begin your day with sunrise coffee, end with sunset cocktails
3. Stargazing Dome Experience – A whimsical retreat for dreamers of all ages
4. Ample On-Site Parking – Effortless access for large groups, luxury vehicles, and VIP transport
★ The Perfect Location:
- Walk to Downtown Jeffersonville – Boutique shopping, acclaimed dining, and vibrant riverfront entertainment
- 2.5 Miles to Downtown Louisville – Discover bourbon distilleries, Churchill Downs, world-class museums, and live music
- Adventure Awaits – Kayaking, biking trails, waterfront festivals, and outdoor concerts just steps away
★ Your Private Riverfront Retreat:
From tranquil mornings on the porch to fireside evenings beneath the stars, Deaconess Guesthouse invites you to slow down, reconnect, and indulge in life’s finer moments. Its historic legacy, stunning river views, and luxury amenities create an experience that transcends the ordinary—a stay where every detail tells a story.
★ Now Booking Exclusive Stays & Private Events, Ideal for:
- Corporate & executive retreats
- Multi-family vacations
- Wedding parties & milestone celebrations
- Friends’ getaways & holiday gatherings
Reserve your stay today and experience Jeffersonville’s most iconic riverfront estate—where history, luxury, and unforgettable memories meet.
★ CONVENIENT LOCATION
The house is centrally located and is within a 10-15 minute Uber/Lyft drive to most locations:
- Big Four Walking Bridge (Connecting KY and IN) - 0.4 miles (2 mins)
- Downtown Louisville/ 4th Street Live - 2.4 miles (6 mins)
- Churchill Downs (DERBY) - 7.7 miles (15 mins)
- KFC Yum Center - 2.3 miles (7 mins)
- Waterfront Park - 3.4 miles (9 mins)
- Papa Johns Stadium (Cardinal Stadium) - 6.4 miles (11 mins)
- University of Louisville - 6.5 miles (12 mins)
- Kentucky Fairgrounds - 6.5 miles (10 min)
- Kentucky Exposition Center - 6.7 miles (11 mins)
- Kentucky Kingdom - 7.4 miles (13 mins)
- Louisville Airport - 8.6 miles (10 mins)
- Highland Festival Grounds - 8.5 miles (12 mins)
- Louisville Mega Cavern - 10.2 miles (19 mins)
- Ford LAP Plant - 10.9 miles (16 mins)
- UPS Worldport - 11.2 miles (20 mins)
- Waverly Hills Sanatorium - 17 miles (30 mins)
- Valhalla Golf Club - 19 miles (27 mins)
PROPERTY HIGHLIGHTS
★ Exclusive Riverfront Retreat near Downtown Louisville/Jeffersonville: Experience an extraordinary blend of historic elegance and modern sophistication at this rare architectural masterpiece—ideally located just minutes from Louisville, Jeffersonville, New Albany and Clarksville.
★ Prime Ohio Riverfront Setting: Wake up to breathtaking panoramic views of the Ohio River and stroll to Jeffersonville’s vibrant downtown, filled with boutique shopping, fine dining, live entertainment and local festivals.
★ Historic Charm Meets Modern Luxury: This meticulously restored landmark showcases timeless craftsmanship, curated interiors and designer finishes—creating an atmosphere that’s both refined and deeply inviting.
★ Scenic Views & Inviting Spaces: Enjoy your morning coffee or evening wine on covered porches and private balconies overlooking the river’s shimmering waters—perfect for unwinding and taking in the view.
★ Designed for Comfort & Connection: With 8 elegant bedrooms and 6 spa-inspired bathrooms, this home is designed for both relaxation and togetherness, offering open, light-filled spaces ideal for family and friends.
★ Chef-Inspired Living: Featuring four gourmet kitchens with premium appliances and upscale touches, this home provides the perfect canvas for culinary experiences and memorable gatherings.
★ Family & Pet Friendly: From cozy reading nooks to kid-friendly zones and pet accommodations, every detail is thoughtfully designed so everyone—two-legged or four—feels perfectly at home.
★ Private Outdoor Oasis: Unwind in the hot tub, gather by the fire pit, relax under the Hyperdome or gazebo and enjoy outdoor dining and lawn games under the starlit sky.
★ Entertainment for Every Occasion: Stay entertained with Smart Roku TVs in every bedroom, indoor and outdoor games and multiple lounge spaces that make every stay as fun as it is relaxing.
★ Perfect for Groups & Celebrations: Ideal for family reunions, retreats, and extended stays, the property offers 4 washer/dryer sets, parking for 8 and flexible gathering spaces designed to bring people together.
★ Your Riverfront Escape Awaits: Discover the ultimate fusion of history, luxury, and location—a one-of-a-kind getaway where every moment feels like a celebration on the banks of the Ohio River.
★ TOP 2025 UPCOMING EVENTS
-Jack O’ Lantern Spectacular: Oct 2025
-Halloween Weekends Louisville South KOA Holiday: Oct 2025
★ OTHER 2025 UPCOMING EVENTS (Including TRADE SHOWS)
-Equipment Expo: Oct 21th to 24th, 2025
-North American International Livestock Exposition: Nov 6th to 20th, 2025
NOTE:
1) Must be 25 or older to book.
2) Please review house rules before booking. Rental Agreement & Security Hold: Guests must e-sign our rental agreement and Must submit a $500 off-platform security hold that will be collected upon signing rental agreement but it will not be placed until 2 days prior to arrival and released 7 days after departure, if no damages are reported. Please note we are API Connected to a hotel-style software called OwnerRez to safely and securely take off-platform security deposits.
3) ** STRICT CANCELLATION for DERBY/ Bourbon & Beyond **
4) Visitors are not permitted unless you make a special request to the host and receive approval.
5) We have exterior surveillance with voice and recording capabilities of the parking area and front door. They are in place for security of guests and the home. We do NOT have interior cameras nor camera in the backyard.
6) The Dome is not recommended for use during hot summer months. We suggest enjoying the other amenities during warmer months for optimal comfort.
7) We cannot accommodate early check-ins or late check-outs for same-day turnarounds.
8) For days without same-day turnarounds, we offer early check-ins and late check-outs at the following rates: $100 for up to 2 hours, $250 for 2 to 4 hours, and a full day's rate for more than 4 hours.
9) Please note that for cancellations of bookings made on platforms other than Airbnb, a Stripe card processing fee of 3% will be deducted from the total refund.
PLEASE REVIEW THE HOUSE RULES BEFORE BOOKING. THANK YOU!

Sleeps24*Louisville*6000SF*Views*YardOasis*HotTub*Dome*Firepit*Pet*Lux Amenities is located in Jeffersonville. Sleeps24*Louisville*6000SF*Views*YardOasis*HotTub*Dome*Firepit*Pet*Lux Amenities provides accommodation, featuring Barbecue/Outdoor Cooking, Child Friendly, Hot Tub, among other amenities. This House features Barbecue/Outdoor Cooking, Child Friendly, Hot Tub, to make your stay a comfortable one.

Sleeps24*Louisville*6000SF*Views*YardOasis*HotTub*Dome*Firepit*Pet*Lux Amenities has 8 Bedrooms , 6 Bathrooms, and max occupancy of 24 people. The minimum rental for this property is 1 nights, but this can change depending on the season you plan on staying. Previous guests have rated it 2, and VRBO labeled it a top-rated House because of the excellent services rendered by the owner or manager of this House, and has consistently provided great experiences for their guests. Most families or guests that use it recommend it to their friends and some of them are repeat guests. House has a friendly neighborhood, and the Jeffersonville has interesting places to visit. If you want to learn more about the House in Jeffersonville, such as places to visit and things to do nearby, you can check below to learn more.